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Free [Ca ] inside the sarcoplasmic reticulum ([Ca ]SR) is difficult to measure yet critically important in controlling many cellular systems. In cardiac myocytes, [Ca ]SR regulates cardiac contractility. We directly measure [Ca ]SR in intact cardiac myocytes dynamically and quantitatively during beats, with high spatial resolution. Diastolic [Ca ]SR (1 to 1.5 mmol/L) is only partially depleted ...
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ژورنال
عنوان ژورنال: Archives of Foundry Engineering
سال: 2016
ISSN: 2299-2944
DOI: 10.1515/afe-2016-0069